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| Player | Cause | Organization |
|---|---|---|
| Matthew Adams | Mental Health | Colts Foundation - Kicking The Stigma |
| Rodrigo Blankenship | Multiple Sclerosis | National Multiple Sclerosis Society |
| DeForest Buckner | The Sexual Abuse & Exploitation of Children | kNot Today |
| Parris Campbell | Youth Education | I Promise Foundation |
| TJ Carrie | Disease Awareness/Prevention | TJ Carrie Foundation |
| Anthony Chesley | Social Justice | Mission Transformation |
| Jack Doyle | Cancer | Riley Hospital for Children |
| Zaire Franklin | Community Outreach | Shelice's Angels |
| Will Fries | Military Appreciation/Support | HeadStrong |
| Jordan Glasgow | Cancer | American Cancer Society |
| Mark Glowinski | Social Justice | Kids' Voice of Indiana |
| Kylen Granson | Youth Education | KG's Kids |
| DeMichael Harris | Disease Awareness/Prevention | American Heart Association |
| T.Y. Hilton | Youth Health/Wellness | Boys and Girls Clubs of Miami-Dade |
| Nyheim Hines | Disease Awareness/Prevention | Muscular Dystrophy Association |
| Brett Hundley | Epilepsy | The Hundley Foundation |
| Kalen Jackson | Mental Health | Project Healthy Minds |
| Ryan Kelly | First Responder Support | Concerns of Police Survivors (C.O.P.S.) |
| Darius Leonard | Disease Awareness/Prevention | Lupus Foundation of American |
| Tyquan Lewis | Disease Awareness/Prevention | Alzheimer's Association |
| Marlon Mack | Community Outreach | Marlon Mack Foundation |
| Kenny Moore II | Disease Awareness/Prevention | Mighty Mason Fund - Riley Children's Foundation |
| Al-Quadin Muhammad | Youth Health/Wellness | Boys & Girls Club of Newark |
| Quenton Nelson | Cancer | The V Foundation |
| Carter O'Donnell | Awareness of missing or murdered Indigenous women across Canada | REDress Project |
| George Odum | Homelessness | Wheeler Mission Ministries + United Way |
| Dezmon Patmon | Mental Health | Hope For The Future |
| Kwity Paye | Youth Health/Wellness | TUFF (The Uniform Funding Foundation) |
| Danny Pinter | First Responder Support | National Fallen Firefighters Foundation |
| Frank Reich | The Sexual Abuse & Exploitation of Children | kNot Today |
| Luke Rhodes | Military Appreciation/Support | Children of Fallen Patriots |
| Isaiah Rodgers | Cancer | Ronald McDonald House |
| Rigoberto Sanchez | Cancer | American Cancer Society |
| Andrew Sendejo | Substance Abuse | D.A.R.E. |
| EJ Speed | Disease Awareness/Prevention | Leukemia and Lymphoma society |
| Taylor Stallworth | Youth Health/Wellness | Won’t Be Denied Foundation |
| Kemoko Turay | Cancer | American Cancer Society |
| Carson Wentz | Community Outreach | AO1 Foundation |
| Christopher Williams | Social Justice | Black Lives Matter |
| Khari Willis | Cancer | American Cancer Society |