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| Player | Cause | Organization |
|---|---|---|
| Azeez Al-Shaair | Disease Awareness/Prevention | Alzheimer's Association |
| Arik Armstead | Youth Education | Armstead Academic Project |
| Alejandro Barrett | Autism | A Walk on Water (AWOW) |
| Jake Brendel | Sudden Cardiac Arrest/Death | Living For Zachary |
| Daniel Brunskill | Disabilities | TR 4 Heart and Soul |
| River Cracraft | Mental Health | Hilinski’s Hope |
| Darrion Daniels | Disease Awareness/Prevention | Lupus Foundation of Northern California |
| Ross Dwelley | Autism | Autism Tree Project Foundation |
| Samson Ebukam | Humanitarian Rights | T & S Foundation |
| Demetrius Flannigan-Fowles | Underserved Youth | IAmYou360 |
| Maurice Hurst | Cancer | Colon Cancer Coalition |
| Dontae Johnson | Youth Health/Wellness | Lucile Packard Children's Hospital |
| David Jones | Homelessness | City Team |
| Kyle Juszczyk | Cancer | Prostate Cancer Foundation |
| Zach Kerr | Disease Awareness/Prevention | Foundation of Sarcoidosis Research |
| Trey Lance | Youth | SW MN Fellowship of Christian Athletes |
| Alexander Mack | Youth Education | Eat Learn Play |
| Mike McGlinchey | Healthcare | Donor Network West |
| Jaylon Moore | Cancer | American Cancer Society |
| Emmanuel Moseley | COVID-19 Relief | University of California San Francisco (COVID-19 Relief Program) |
| Josh Norman | Youth | STARZ24 |
| Taybor Pepper | Underserved Youth | Gamers Outreach Foundation |
| Deebo Samuel | Youth | Deebo Samuel Foundation |
| Mohamed Sanu | Cancer | Camp Okizu |
| Trent Sherfield | Cancer | Sarcoma Foundation of America |
| Kentavius Street | Social Justice | Until freedom |
| Laken Tomlinson | Mental Health | NAMI |
| Fred Warner | Mental Health | Born this Way Foundation |
| Trent Williams | Cancer | Sarcoma Foundation of America |
| Tavon Wilson | Gun Violence | The Trigger Project |
| Mitchell Wishnowsky | Animal Justice | Hope for Paws |
| Charlie Woerner | Humanitarian Rights | The Nazarene Fund |
| Eddie Yarbrough | Special Olympics | Special Olympics |