| Most Sacks, Career | |
| 16.0 | Willie McGinest, New England, 18 games |
| 14.5 | Bruce Smith, Buffalo, 20 games |
| 12.0 | Reggie White, Philadelphia-Green Bay, 19 games |
| Most Sacks, Game | |
| 4.5 | Willie McGinest, AFC-FR: New England vs. Jacksonville, 2005 |
| 3.5 | Rich Milot, NFC-D: Washington vs. Chicago, 1984 Richard Dent, NFC-D: Chicago vs. N.Y. Giants, 1985 |
| 3.0 |
Richard Dent, NFC-D: Chicago vs. Washington, 1984 Garin Veris, AFC-FR: New England vs. N.Y. Jets, 1985 Gary Jeter, NFC-D: L.A. Rams vs. Dallas, 1985 Carl Hairston, AFC-D: Cleveland vs. N.Y. Jets, 1986 (OT) Charles Mann, NFC-D: Washington vs. Chicago, 1987 Kevin Greene, NFC-FR: L.A. Rams vs. Minnesota, 1988 Greg Townsend, AFC-D: L.A. Raiders vs. Cincinnati, 1990 Wilber Marshall, NFC: Washington vs. Detroit, 1991 Fred Stokes, NFC-FR: Washington vs. Minnesota, 1992 Pierce Holt, NFC-D: San Francisco vs. Washington, 1992 Tony Casillas, NFC: Dallas vs. San Francisco, 1992 Gerald Williams, AFC-FR: Pittsburgh vs. Kansas City, 1993 Chad Brown, AFC-FR: Pittsburgh vs. Indianapolis, 1996 Reggie White, SB: Green Bay vs. New England, 1996 Warren Sapp, NFC-D: Tampa Bay vs. Green Bay, 1997 Trace Armstrong, AFC-FR: Miami vs. Seattle, 1999 Michael McCrary, AFC-FR: Baltimore vs. Denver, 2000 Willie McGinest, AFC-D: New England vs. Tennessee, 2003 |
| Sacks have been compiled since 1982. | |