The 49ers are in the midst of a major offseason makeover. But questions surround San Francisco about its direction. Can new coach Jim Tomsula and Colin Kaepernick right the ship?

Colin Kaepernick struggled again for the 49ers on Thursday night in a pivotal loss to the Seahawks. Has Kaepernick regressed and are the Niners behind the eight ball in terms of trying to crack the postseason?

The Buffalo Bills could be sans two playmakers for Sunday's pivotal clash against the Chiefs as Sammy Watkins and Fred Jackson both are questionable. Here's the latest on the Week 10 injury report.

Stevie Johnson has been productive for the San Francisco 49ers this season, but remains buried at No. 4 on the depth chart. The wideout said he's not frustrated because the players in front of him aren't weak.

Opportunity is knocking for running backs Tre Mason and Bryce Brown, Chris Wesseling writes. Find out who else is due for an uptick in playing time in the Week 8 Snap Report.

How high do the Dallas Cowboys fly in the latest edition of the Power Rankings? How low do the Pittsburgh Steelers go? Elliot Harrison reassesses the NFL pecking order heading into Week 7.

Like their coach Jim Harbaugh, this San Francisco 49ers team appears to revel in drama. Anquan Boldin and his teammates seem to play their best when things look dark, like on "Monday Night Football."

On the strength of Colin Kaepernick's third career game over 300 passing yards, the San Francisco 49ers went into St. Louis and handed the Rams a 31-17 loss Monday night.

Frank Gore and the San Francisco 49ers spoiled Alex Smith's return to the Bay Area, as the Niners beat the Chiefs at Levi's Stadium.

The San Francisco 49ers still boast productive starters in Patrick Willis and Frank Gore. But are they deep enough to keep up with the division-rival Seattle Seahawks on both sides of the ball?

The 49ers traded for Stevie Johnson with the expectation that he was going to be the No. 3 receiver. However, Johnson is still competing for the role and acknowledged he's no longer a featured part of the offense.

The Indianapolis Colts have been hit hard by injuries in this summer's "war of attrition." Chris Wesseling tells you what else you need to know from Friday's training camp action.

Jim Harbaugh revealed Friday that Michael Crabtree is "working through something" and could miss a week or two of practices. Will the 49ers be without his fellow receiver Brandon Lloyd as well?

Brandon Lloyd signed with the San Francisco 49ers in April after a season away from the NFL. Surprisingly, the past year was "kind of a relief" for the wide receiver. Does he have a shot at a roster spot?

DeAndre Hopkins of the Texans finished second among rookie wide receivers in a roller-coaster 2013 season. Chris Wesseling examines his breakout potential in Bill O'Brien's offense.

San Francisco 49ers coach Jim Harbaugh is expecting big things from quarterback Colin Kaepernick. Could the new offensive acquisitions be the reason why?

The 49ers spent last season struggling with depth at receiver. That shouldn't be a problem in 2014, with the newly acquired Stevie Johnson saying: "The defense has gotta pick their poison."

South Carolina's Bruce Ellington was drafted by the 49ers in the fourth round (106th overall). Ellington, cousin of Cardinals running back Andre Ellington, adds some speed to the Niners' receiving corps.

Forget about the division Percy Harvin plays in. If the talented receiver can stay healthy in 2014, there's a lot to like about the schedule he'll face this season.