Details: Saturday, 3:30 p.m. ET, ABC/ESPN2
What's at stake? It's hard to imagine the Spartans won't have at least something of an emotional letdown after the miracle finish to beat rival Michigan last week. But if they do start slow, it had better pass quickly -- MSU is still unbeaten and in good shape for both Big Ten and College Football Playoff contention.
Matchup to watch: Indiana OT Jason Spriggs vs. Michigan State DE Shilique Calhoun.

Game picks:
Brandt: Michigan State, 41-31
Brooks: Michigan State, 31-28
Davis: Michigan State, 44-41
Goodbread: Michigan State, 20-13
Jeremiah: Michigan State, 28-21
Reuter: Michigan State, 27-21
Zierlein: Michigan State, 31-27

Details: Saturday, 7 p.m. ET, ESPNU
What's at stake? LSU has nothing to gain and everything to lose here in a non-conference game that might be closer than people think. WKU QB Brandon Doughty is one of the nation's best, and he just might keep the Hilltoppers hanging around awhile in this one.
Matchup to watch: Western Kentucky QB Brandon Doughty vs. LSU DB Jalen Mills.

Game picks:
Brandt: LSU, 47-31
Brooks: LSU, 28-0
Davis: LSU, 33-27
Goodbread: LSU, 38-21
Jeremiah: LSU, 31-14
Reuter: LSU, 38-21
Zierlein: LSU, 35-28

Details: Saturday, 8 p.m. ET, ABC
What's at stake? J.T. Barrett gets his first start of the season and a chance to claim the Buckeyes' quarterback job for the balance of the year. It's also a big chance for Rutgers receiver Leonte Carroo, who is dealing with an ankle injury, to show NFL scouts what he can do against a top-notch secondary.
Matchup to watch: Ohio State CB Eli Apple vs. Rutgers WR Leonte Carroo.

Game picks:
Brandt: Ohio State, 48-21
Brooks: Ohio State, 45-20
Davis: Ohio State, 56-21
Goodbread: Ohio State, 28-9
Jeremiah: Ohio State, 42-21
Reuter: Ohio State, 42-17
Zierlein: Ohio State, 38-14

Details: Saturday, 3:30 p.m. ET, ABC/ESPN2
What's at stake? Big 12 title hopes for Oklahoma are all but dashed with a loss to the Red Raiders, because it would be OU's second league loss in a conference with three teams still undefeated.
Matchup to watch: Texas Tech DB J.J. Gaines vs. Oklahoma WR Sterling Shepard.

Game picks:
Brandt: Oklahoma, 50-28
Brooks: Oklahoma, 65-62
Davis: Oklahoma, 50-35
Goodbread: Oklahoma, 48-35
Jeremiah: Oklahoma, 52-35
Reuter: Oklahoma, 48-35
Zierlein: Oklahoma, 49-31

Details: Saturday, noon ET, ABC
What's at stake? UM coach Al Golden desperately needs a win this season that can galvanize support for himself and the program. A win over a 6-0 Clemson team with legitimate College Football Playoff hopes would qualify.
Matchup to watch: Clemson DE Shaq Lawson vs. Miami QB Brad Kaaya.

Game picks:
Brandt: Clemson, 28-27
Brooks: Clemson, 30-20
Davis: Clemson, 38-20
Goodbread: Clemson, 27-17
Jeremiah: Clemson, 35-28
Reuter: Clemson, 35-21
Zierlein: Clemson, 28-20

Details: Saturday, 7 p.m. ET, ESPN2
What's at stake? The Seminoles look to stay unbeaten against a team that's now essentially playing for pride in Georgia Tech. That and the Yellow Jackets' triple-option offense could combine to give the Seminoles a tough game.
Matchup to watch: FSU OL Ryan Hoefeld vs. Georgia Tech DL Jabari Hunt.

Game picks:
Brandt: Florida State, 34-24
Brooks: Florida State, 30-17
Davis: Florida State, 48-40
Goodbread: Georgia Tech, 35-30
Jeremiah: Florida State, 31-21
Reuter: Florida State, 45-28
Zierlein: Georgia Tech, 28-27

Details: Saturday, 7:30 p.m. ET, FOX
What's at stake? USC will try to get its first win under interim coach Clay Helton, while Utah looks to remain the top-ranked team in the Pac-12. The Utes need a strong defensive effort here and they have the secondary to contain the Trojans' passing attack.
Matchup to watch: Utah RB Devontae Booker vs. USC LB Su'a Cravens.

Game picks:
Brandt: USC, 31-24
Brooks: USC, 21-20
Davis: Utah, 35-28
Goodbread: Utah, 42-31
Jeremiah: Utah, 35-27
Reuter: Utah, 31-28
Zierlein: USC, 28-24

Details: Saturday, 3:30 p.m. ET, CBS
What's at stake? Alabama carries an eight-game series win streak into the game that is becoming a fast-growing sore point for Vols fans. The Crimson Tide's rebound since losing to Ole Miss has been impressive, but isn't yet complete if Alabama wants to win the SEC again.
Matchup to watch: Tennessee RB Jalen Hurd vs. Alabama LB Reggie Ragland.

Game picks:
Brandt: Alabama, 38-17
Brooks: Alabama, 21-3
Davis: Alabama, 31-30
Goodbread: Alabama, 31-23
Jeremiah: Alabama, 38-24
Reuter: Alabama, 27-17
Zierlein: Alabama, 35-24

Details: Thursday, 9 p.m. ET, ESPN
What's at stake? The Golden Bears very much need to bounce back from a loss to Utah in which star quarterback Jared Goff threw five interceptions.
Matchup to watch: Cal QB Jared Goff vs. UCLA CB Ishmael Adams.

Game picks:
Brandt: UCLA, 42-35
Brooks: California, 24-20
Davis: UCLA, 44-40
Goodbread: UCLA, 30-26
Jeremiah: UCLA, 27-24
Reuter: UCLA, 35-28
Zierlein: California, 35-34

Details: Saturday, 7 p.m. ET, ESPN
What's at stake? With one SEC loss each, both teams face a must-win to stay in SEC West contention. The loser isn't likely to get back into the SEC race, while the winner will take a significant step closer to the goal.
Matchup to watch: Texas A&M DE Myles Garrett vs. Ole Miss OT Laremy Tunsil.

Game picks:
Brandt: Ole Miss, 35-28
Brooks: Texas A&M, 30-29
Davis: Texas A&M, 41-40
Goodbread: Ole Miss, 28-27
Jeremiah: Ole Miss, 34-28
Reuter: Ole Miss, 34-31
Zierlein: Ole Miss, 28-24