September 30, 2001 Tom Brady makes the first start of his NFL career, and he leads the Patriots to a 44-13 win. Brady didn't throw a touchdown, but he didn't throw an interception, either. Manning was picked off three times. Brady is heard saying, "This starting stuff is easy." Associated Press

October 21, 2001 Tom Brady shows a little more in the rematch against Manning, as he tossed three touchdowns in a 38-17 win. The Patriots would go on to win the Super Bowl. Associated Press

November 30, 2003 Peyton Manning throws four touchdowns against the Patriots, but Tom Brady's fourth quarter score to Deion Branch was the difference in the Patriots' 38-34 victory. Associated Press

January 18, 2004 Peyton Manning throws four interceptions in the 2003 AFC Championship Game as the Patriots move on to win their second Super Bowl. Brady is seen here asking if Manning is even trying in these games. Charles Krupa/Associated Press

September 9, 2004 The Patriots open the 2004 season with another victory over Peyton Manning and the Colts. Good news, Peyton only throws one interception in this game. That's progress. Charles Krupa/Associated Press

November 7, 2005 The football world is stunned when Peyton Manning throws three touchdowns as the Colts destroy the Patriots, 40-21. Many wait around for the handshake to see if Ashton Kutcher emerges to tell everybody they've been Punk'd. He doesn't, and Peyton ends a six-game losing streak to Tom Brady. Associated Press

January 16, 2005 The Patriots hold Peyton Manning and the Colts to just three points in this divisional round playoff game. It looks like Tom Brady just told Peyton a joke about the bear and the hunter in the woods. Charles Krupa/Associated Press

November 5, 2006 Peyton Manning makes it two consecutive wins over Tom Brady, as it's the Patriots' quarterback who throws four interceptions in the loss. Many football enthusiasts wonder if the plot of "Face Off" is real and the quarterbacks have been switched. Winslow Townson/Associated Press

November 4, 2007 Tom Brady has to rally the Patriots this time with two fourth-quarter touchdown passes to Wes Welker and Kevin Faulk as New England improves to 9-0 with a 24-20 victory. Suddenly, things seem right again in the football world. David Stluka/Associated Press

January 21, 2007 In something nobody saw coming, Peyton Manning actually rallies the Colts for a clutch victory in the AFC Championship Game. If you look at the photo, Tom Brady has the same look on his face as an older brother does when his mother tells him to let the little brother win. Manning would go on to win the Super Bowl in the most unlikely title victory since David Arquette won the WCW heavyweight title. Associated Press

November 15, 2009 In one of the most bizarre endings to a football game, Patriots coach Bill Belichick goes for it on fourth and short deep in his own territory late in the fourth quarter. The move backfires and Peyton Manning wins it with a 1-yard touchdown pass to Reggie Wayne. Tom Brady is seen here saying, "Yeah, I don't know what he was thinking, either." (Actually, it was the right move by Belichick.) Darron Cummings/Associated Press

November 21, 2010 Tom Brady wins the final installment of this rivalry (and presumably the last one as Patriots and Colts, respectively) with a win, 31-28. Peyton Manning valiantly tries to rally his team late in the game, but they are done in by his three interceptions. Manning done in by interceptions? Hard to believe, but it's true. Winslow Townson/Associated Press