NFL Media Insider Ian Rapoport reported Tuesday that the Colts have fired defensive coordinator Greg Manusky. The team confirmed the news on Wednesday.
Pagano hinted Monday night on NFL Network changes to the staff could be coming.
"We've had a bunch of discussions, like I said, and we've got a lot of things like everybody else that's done playing," Pagano said. "There are teams obviously that are still in preparation (mode); the teams that made the playoffs, obviously. But everybody else is still in the evaluation mode now, and we're going to roll up our shirtsleeves and go to work. And, again, everything we do is based on two things: What's best for this team and what gives us the best chance to win."
The Colts' defense under Manusky and Pagano hasn't been solid during their three-year stint together. The unit improved from 2014, but still finished 27th in total yards per game (379.1) and 25th in points per game allowed (25.5) in 2015.
Perhaps Pagano will take a bigger role in the defensive play-calling moving into 2016.
The bigger issue is the overall lack of young talent on the defensive side of the ball. Rookie defensive linemen David Parry and Henry Anderson showed promise this season, but general manager Ryan Grigson will need to stockpile more young playmakers for things in Indy to change.