Rex Ryan: LeSean McCoy 'ready to roll' in Week 1

Bills running back LeSean McCoy is "ready to roll," according to head coach Rex Ryan.

Despite a growing uncertainty that the franchise back would play in the season-opener against the Colts with a hamstring injury, it seems like Ryan is more than ready to unveil his new weapon Week 1, who fully participated in Wednesday's practice.

When asked if McCoy would be on a pitch count, Ryan quipped: "Whatever, 100 (carries)."

This is good news for the Bills in the short term, at least. Assuming there will not be any lingering issues with McCoy's hamstring, the Bills need to sync their offense as soon as possible. Finding the right way to use McCoy will be paramount.

However, if this is the preamble to a string of injuries for McCoy, the Bills will be out a lot of money -- and expectations.

Other injury news around the NFL...

1. Giants wide receiver Victor Cruz did not participated in practice Wednesday and almost certainly won't be on the field for the season opener. Tom Coughlin told reporters that Cruz's calf injury will keep him off the field as it has often of late. He went through additional measures to reaffirm that Cruz is not being bothered by the torn patellar tendon that ended his season a year ago, but does it matter? The Giants wideout clearly needs more time to mend his lower body before getting back on the field. Speed is his greatest weapon.

2. Good news for the Packers as wideout Randall Cobb (shoulder) returned to practice and was officially listed as a limited participant by the team. This affirms Cobb's previous declaration last week that he didn't plan on missing any games.

3. The Patriots have ruled starting center Bryan Stork out with a concussion for New England's season opener against the Steelers and have placed him on IR Boomerang.

4. Star second-year wideout Mike Evans did not participate in practice for the Buccaneers on Wednesday. Evans missed the remainder of the preseason after sustaining a hamstring injury against the Bengals in the third game.

5. Dolphins tackle Branden Albert (knee) doesn't seem to have any doubts as to his Week 1 status.

This is exceptional -- but not unexpected -- confidence coming from Albert, who has been working on the field for weeks now and fully participated in Wednesday's practice. The team's anchor at left tackle is an absolute necessity in order for the Dolphins to continue their playoff push. Assuming pieces like Billy Turner and Ja'Wuan James can develop around Albert, this can be a formidable unit moving forward.

6. Cowboys quarterback Tony Romo is taking Wednesday off from practice, according to coach Jason Garrett. Romo did not practice on Wednesdays during the 2014 season and Garrett said he will follow that plan -- at least for Week 1.

7. Bills wideout Percy Harvin did not participate in the Bills' Wednesday practice. Harvin has been battling a hip issue all summer.

8. Panthers center Ryan Kalil returned to practice Wednesday as a limited participant after taking time to recover from a sprained knee injury.

9. Browns coach Mike Pettine told the media Wednesday that Johnny Manziel had some soreness coming off of Monday's throwing session, but "that was expected." The second-year signal-caller was a limited participant in practice, and should be set to suit up on Sunday.

He added that rookie running back Duke Johnson and cornerback Pierre Desir both passed concussion protocol and returned to practice as limited participants.