Jim Kelly will take the field before the Hall of Fame Game.
Kelly completed radiation in May and chemotherapy sessions to treat sinus cancer, which spread from his jaw. The Hall of Famer was inducted in 2002.
"I have always said that God willing, I will be back in Canton every summer," Kelly said. "This year especially, I am so thankful that I can be on hand to share in a great weekend that shines the spotlight on the Buffalo Bills. There isn't a person more deserving of joining the Hall of Fame than my teammate and friend Andre Reed."
The Bills' legendary signal-caller will represent Buffalo as an honorary captain, while former linebacker and 2006 HOF inductee Harry Carson will be the New York Giants' honorary captain when the teams meet to open the NFL's preseason.
"It is also a great honor for me to represent the Bills organization at the coin toss to kick off the season," Kelly said. "The entire experience will bring back many great memories from 2002 when so many of the Bills family -- fans, players, and staff -- joined me in Canton for one of the most memorable times of my life."
Along with Reed, inductees this year include Derrick Brooks, Ray Guy, Claude Humphrey, Walter Jones, Michael Strahan, and Aeneas Williams. The ceremony takes place Aug. 2.