Speaking to the media Thursday, John Harbaugh said he couldn't comment on the suspension until the league announced it.
The coach did, however, say the team has been preparing for Rice's punishment and that he spoke to the running back on the field during practice.
"It's just part of the process," Harbaugh said. "We always said from the beginning that the circumstances would determine the consequences. There are consequences when you make a mistake like that. I stand behind Ray, he's a heck of a guy, he's done everything right since. He makes a mistake, he's gonna have to pay a consequence.
"I think that's good for kids to understand it works that way, that's how it works, that's how it should be. We'll move forward, and the next guy will have to step up and Ray will be back when the time comes. It's not something that we're dwelling on, we're not worrying about it, we're just moving forward."
In a statement, Rice reiterated his remorsefulness for the incident.
"It is disappointing that I will not be with my teammates for the first two games of the season, but that's my fault," Rice said. "My goal is to earn back the trust of the people, especially the children, I let down because of this incident.
"I am a role model and I take that responsibility seriously. My actions going forward will show that."
"While not having Ray for the first two games is significant to our team, we respect the league's decision and believe it is fair."
Harbaugh glowed about the collection of runners Newsome has compiled in his backfield, which would mitigate the loss of Rice early in the season.
"I think we have a lot of depth at running back, we'll just see how it plays out, a lot of competition in there and I like our guys and looking forward to seeing how they do," he said.