The team announced Wednesday it placed Moala on the injured reserve list.
The defensive lineman partially tore his ACL after colliding with a teammate during OTAs and his knee buckled, NFL Media Insider Ian Rapoport reported, according to a source informed of the situation.
The tear occurred in Moala's right knee, the same knee injury he suffered in Nov. 2012.
The 28-year-old re-signed with the Colts this offseason as a rotational player.
Moala started six games in 2013 and earned the second-most snaps along the Colts' defensive front. He produced 1.5 sacks and 21 quarterback hurries, according to Pro Football Focus.
With the Colts adding Arthur Jones in the offseason -- who is expected to play multiple spots along the defensive line -- Moala's playing time likely was to decrease. However, on a thin Colts defense, every loss hurts.