The second-year coach detailed his situation in a statement released through the team late Tuesday.
"During a recent doctor's visit, it was discovered that I had a cancerous mole on my skin, which has since been removed," the statement read. "The only follow up required is to have my moles checked every three months and that basically is the end of the story. The recent extraction procedure will have no effect on my ability to coach the team moving forward."
The announcement comes after the Bills' official website published a story with missing information under the headline, "Coach Marrone announces he has cancer." The story was pulled from the team's website shortly after it was discovered and began to spread on social media.
Marrone's announcement is the latest episode in a difficult offseason for the Bills' organization. Hall of Fame quarterback Jim Kelly is in treatment following a reoccurrence of cancer in his jaw. The team also lost its founding owner, Ralph Wilson Jr., who died last month at the age of 95.
Marrone is with his team this week for the start of the Bills' offseason training program. Buffalo went 6-10 in Marrone's first year at the helm.