The Broncos announced Saturday that Wolfe has been downgraded to out after falling ill on Friday's team bus ride to the airport.
"Derek Wolfe is alert and recovering in a Denver hospital after experiencing seizure-like symptoms on Friday," the Broncos said in a statement. "He underwent extensive testing and is now being treated accordingly by doctors, who will continue to monitor his condition."
Interim coach Jack Del Rio confirmed earlier this week that first-round draft pick Sylvester Williams "certainly is going to get plenty of opportunity" to play now that there's a void up front. The defensive tackle had been a healthy scratch in two of the past four games.