LeSean McCoy injured his right hamstring at the end of a 16-yard run in the second quarter. McCoy limped off the field after rolling around in obvious pain.
After getting treatment from a trainer on the sideline, the NFL's rushing leader hobbled to the locker room with just less than four minutes remaining before halftime.
The Eagles have not clarified if the injury merely is a cramp or something more serious such as a strain or tear. Backup Bryce Brown will take over as the primary ball carrier, with Chris Polk and Matthew Tucker around for depth.
UPDATE: McCoy was back on the field after halftime and started the third quarter with the rest of the Eagles' offense. McCoy previously was listed as questionable to return.