Spiller is shaping up as a game-time decision.
"If I can go, I'll go," Spiller said Tuesday, via ESPN.com. "If I can't, I can't."
Although Spiller was walking with a heavy limp Tuesday, he said there is "not much swelling" in his ankle.
"It felt good. To be honest, I didn't think I would be able to jog today. So that was an encouraging sign," Spiller added. "Tomorrow will be a huge day for us, to see what the reaction will be."
Regardless of Spiller's availability, the Bills' ground attack is going to have a tough row to hoe with two banged-up tailbacks squaring off against an imposing Browns front seven that has allowed just 79 rushing yards per game.