Reggie Bush is inactive Sunday after injuring his knee in Week 2, the team announced. Bush wanted to play, NFL Media Insider Ian Rapoport reported earlier Sunday, but the Lions felt being cautious with their starting running back was the prudent move.
It's a huge loss for the Lions, who lack playmakers without Bush on the field.
Bush added an important dimension as a pass-catcher out of the backfield, taking advantage of teams loading up on wide receiver Calvin Johnson.
With Bush out, backup Joique Bell will start and earn the majority of the carries for the Lions. Rookie running back Theo Riddick most likely will be No. 2. Riddick has displayed some ability taking over Bush's role in the pass game and on wide runs. Former second-round draft pick Mikel Leshoure is active for the first time this season and probably will spell Bell for stretches as the third back.