Coach Chuck Pagano made the announcement Monday.
Hickman injured his right foot early in the second quarter of Sunday's 44-20 preseason loss to the Buffalo Bills and limped off the field after getting injured on a running play. Pagano said X-rays showed the Lisfranc injury and doctors have recommended surgery.
It's another blow for the Colts, who already have lost defensive tackle Brandon McKinney for the season with a knee injury and will be without tight end Dwayne Allen for at least a couple of more weeks because of a foot injury.
Cornerback Cassius Vaughn is listed as day-to-day after X-rays were negative on his wrist.
Copyright 2013 by The Associated Press