Manning surpassed former Miami Dolphins great Dan Marino on the all-time list with the 421st touchdown pass of his career -- a 13-yard strike to Demaryius Thomas in the back of the end zone. Manning finished the game completing 25 of 42 passes for 270 yards and three touchdowns.
Top 10 photos of 2012: Week 11take a look at the best action photos from around the league in Week 11.
But it wasn't all good news for the Broncos.
Broncos running back Willis McGahee hurt his right knee early in the second quarter when he was tackled by Chargers defensive back Quentin Jammer. McGahee did not return to the game after initially being listed as questionable. He had 55 yards on seven carries, along with one catch for 18 yards.
McGahee is scheduled to have an MRI on his knee Monday, according to The Denver Post.
Jammer was shaken up after tackling McGahee and left the game with a calf injury.
Broncos special-teams stalwart Omar Bolden suffered a concussion late in the first quarter and did not return. Chargers linebacker Larry English also left the game in the first half with a leg injury.
The Associated Press contributed to this report.