Sproles missed the last two games with a broken hand that required surgery, but he was believed to have a chance to return Sunday. The combination of Chris Ivory, Mark Ingram and Pierre Thomas has picked up the slack in Sproles' absence.
The Saints (4-5) are in must-win mode after an 0-4 start. The good news: They probably can afford to go without Sproles against the three-win Raiders, who rank 24th in the NFL against the pass. Drew Brees and the league's No. 2 pass offense should have plenty of success regardless.
UPDATE: The team has announced Sproles is officially inactive for the game.
Follow Kareem Copeland on Twitter @kareemcopeland.