NFL.com and NFL Network reporter Ian Rapoport has his thoughts on the game:
Why this game is intriguing: I'll admit, I'm a sucker for the San Francisco 49ers. Love watching 'em. This game isn't eye-popping on paper, even though it's an NFC West matchup. But I'm excited to see how it turns out, mainly because the Rams are one of the few teams that can take the Niners out of their game. Quarterback Alex Smith is coming off one of the most efficient outings in NFL history, with a successful run game giving Smith and his receivers easy access to endless completions against the Arizona Cardinals in Week 8. That'll be a challenge to repeat against a Rams team that has shown flashes of being able to stop the run and can really cover the ball in the air. The physical Cortland Finnegan and the promising Janoris Jenkins will be on the case for St. Louis. Niners receiver Randy Moss hasn't been lighting up the stat sheet, but he still draws double-coverage and opens up the field. My bet is that he won't this time, though, as either corner will be tasked with roughing him up. That extra defender will help St. Louis. Of course, if the 49ers' front four is in Rams quarterback Sam Bradford's face all afternoon, none of that will matter much.
On Twitter: #STLvsSF