Luck was 30-of-48 passing with two TDs and broke Cam Newton's previous mark of 422 yards, set last season. And it came on the day when Colts coach Chuck Pagano returned to Lucas Oil Stadium for the first time since being diagnosed with leukemia.
Indianapolis (5-3) has won three in a row.
Miami (4-4) received another strong performance from Ryan Tannehill, too. The rookie quarterback went 22-of-38 passing for 290 yards and one TD.
Copyright 2012 by The Associated Press