Pagano was diagnosed acute promyelocytic leukemia, which is easier to treat than other forms of acute leukemia and is potentially curable.
Pagano was released from the hospital Monday and visited the team facilities this week. He begins his next round of chemotherapy this coming week, and it's not known when Pagano be able to resume coaching duties.
The Colts were admittedly inspired that first week without Pagano. There will be a similar feelings with their leader in the house.
UPDATE: Pagano is at the Colts' stadium and will address the team before the game, Breer reports.
Follow Kareem Copeland on Twitter @kareemcopeland.