Owner Jim Irsay informed his Colts after the game that Pagano had been sent home from IU Health Simon Cancer Center, according to The Star. Players didn't know about Pagano's release until Irsay told them that the coach had watched their win from home, The Associated Press reported.
The Colts later tweeted a video of the moment Irsay told his team about Pagano's status.
"He was on the doctors, on them and on them and on them, and finally they said, 'OK, Coach, we can't take it anymore, you're too tough. We're going to let you go,' " Irsay said. "So he enjoyed this from his house, which means so much to him, to be back in his own home."
Offensive coordinator and interim coach Bruce Arians told The AP that Pagano had been in the hospital receiving treatment since Sept. 26, and though he'll continue to undergo treatment for several more weeks, he can at least stay at his house.
Pagano's physician, Dr. Larry Cripe, attended Sunday's game in person, but he only would say the coach was in good spirits and progressing well, according to The AP.
The Associated Press contributed to this report.