For football historians, Karras signified a new NFL era. His year-long suspension, along with Green Bay Packers golden boy Paul Hornung's, for gambling on football helped define Pete Rozelle's era as NFL Commissioner.
"I haven't done anything to be ashamed of, and I'm not guilty of anything" Karras said after the suspension in the book, "America's Game," despite publicly admitting he previously bet on games. (Sound familiar to any current story?)
During Karras' year away from football, he tended bar in Detroit. And then he was a first-team All-Pro the following year.
For people of my generation, Karras was George Popodalopus from "Webster."
For lovers of football books, Karras was the most colorful character in George Plympton's classic "Paper Lion" and the follow-up "Mad Ducks and Bears." He also played himself in the movie version of "Paper Lion." The book changed his world. Karras called the 40th reunion of the characters in the book the third-biggest thrill of his life.
"The first two were falling in love, twice," he told the Detroit Free Press in 2003.
Karras wrote an underrated autobiography, "Even Big Guys Cry," that didn't pull any punches about why he went to the University of Iowa. (Karras said he had to take a pay cut when he went from Iowa to the Lions.)
For "Monday Night Football" fans, Karras was one of the most bizarre and funny color men the show has ever seen.
For someone like me, Karras is one of the biggest connections to understanding an entire free-wheeling era of football. Before "Prime Time," Karras knew how to make himself larger than life in a fledgling sport.
Karras' personality was so big that his play on the field tends to get lost in the shuffle. Don Shula once was asked which player who isn't enshrined in Canton deserves to be there.
Unprompted, he said one name: Alex Karras.
For fans of 1960s football, that's how Karras will be rememberd.
Follow Gregg Rosenthal on Twitter @greggrosenthal.