A groin injury has nagged since Week 1 and will sideline Jennings against the Indianapolis Colts on Sunday. The Milwaukee Journal Sentinel reported the Packers will be cautious with the two-time Pro Bowl receiver. They want him 100 percent when he returns, so he could be out several weeks.
"Greg is unable to play, and that's unfortunate," Packers offensive coordinator Tom Clements told the Journal Sentinel's Tom Silverstein. "But we'll have guys in there that we're confident in, and when they're open, we'll get them the ball, and when someone else is open, we'll get them the ball.
"You miss a guy like Greg, but there's not much you can do about it."
The offense, however, changes without Jennings. His quickness and crisp routes could split deep safeties and open opportunities for other receivers. The Packers haven't had as many deep-ball connections in 2012 and have worked a shorter pass game. Jennings hasn't been himself since Week 1, which has played a part in the adjustment.
"When Greg Jennings is on the field, we definitely have a chance to be a very good offenes," Packers coach Mike McCarthy said. "I still think we can play a different way and play without Greg and still be very good. That's the game of football."
Many around Green Bay believe there's little chance Jennings re-signs. He's in line for his last major payday, while quarterback Aaron Rodgers, linebacker Clay Matthews and nose tackle B.J. Raji need to be extended in upcoming seasons. Jennings seems to be the odd man out.
These next few weeks could be a glimpse of the future.
Follow Kareem Copeland on Twitter @kareemcopeland.