Manning opened the game by leading the Broncos on an 80-yard touchdown drive -- their first opening-quarter touchdown of the season -- and Denver never trailed.
Denver running back Willis McGahee ran for 112 yards for his 32nd-career 100-yard game.
The Broncos held Darren McFadden to 34 yards on 13 carries, and Carson Palmer, who last week led the Raiders to a comeback win over the Pittsburgh Steelers, never got on track. He finished 19-of-34 passing for 202 yards.
Copyright 2012 by The Associated Press