La Canfora also reported the third-year pro has a sprained acromioclavicular joint, not a separated shoulder. Bills coach Chan Gailey said the injury isn't as grave as it appeared, and he hasn't ruled out Spiller for Week 4, but his return is unlikely.
"I like my chances," Jackson told the team's official website Monday, placing his status at 70 to 75 percent. "If we like what we see, then I'll be out there Sunday."
The Bills went into the season with the challenge of splitting carries between Jackson and Spiller. That hasn't been a problem so far.
We've seen how dangerous this Bills team can be when these players are on the field. Gailey has done an effective job of creating space for his running backs in Buffalo's spread offense, and even Tashard Choice looked like a different player against Cleveland. The Bills are a running back's paradise in this scheme -- if they can stay on the field.
Follow Marc Sessler on Twitter @MarcSesslerNFL.