Revis suffered a mild concussion last Sunday, and Ryan indicated the protocol involved in clearing concussed players led to the decision. With the team's defensive star sidelined, the Jets will turn to former first-round draft pick Kyle Wilson to fill the void.
"We have a lot of confidence in Kyle Wilson, obviously, he has to step up in a starter role which he's ready for," Ryan said. "It will be good to get (safety) Eric Smith back, we think he's ready to roll."
Smith will return to the lineup after missing Week 1 with injuries to his knee and hip.
"What we've always said, is the guys that are stepping up in this case, the guys who step up and replace a guy have to maintain that level, or even a little better," Ryan said. "In this case, we'll take a little less with the Darrelle Revis deal."
Ryan said the Jets will also be without tight end Dustin Keller, who missed practices late in the week after developing increased soreness in his troublesome hamstring. Linebacker Brian Thomas also has been ruled out.
The Jets are suddenly shorthanded for a road game that already posed a significant challenge. Ryan better have something special in his bag of tricks.
Follow Dan Hanzus on Twitter @danhanzus.