Coach Romeo Crennel, however, said he's not concerned about when Bowe, who's upset over his contract situation, will return.
"We're going to win with whoever we have," Crennel said. "If he's with us, we'd like that to happen. If he's not, then we're going to work with the guys we've got here."
Bowe is reportedly unhappy the team placed the franchise tag on him this offseason and has no plans to sign it. He is believed to be seeking a long-term deal.
Bowe would make $9.5 million in 2012 if he signed his franchise tender.
Already thin at the position, the Chiefs were also missing last year's first-round pick Jonathan Baldwin during Friday's practice session because of a migraine. The team previously said that Dexter McCluster, their jack-of-all-trades weapon, will be used at wideout this season.
Bowe put together a breakout season in 2010, when he hauled in 15 touchdowns. He followed that up by catching 81 passes for 1,159 yards and five TDs this past season.