3 Key Moments
Week 6 vs. Giants
The rematch of the NFC Championship Game will give the 49ers an opportunity to make amends for a disappointing end to their season and could play a pivotal role in determining home-field advantage for the 2012 postseason.
Week 12 at Saints
The slobber-knockin' postseason battle between these NFC rivals made this contest an intriguing watch when schedule-makers originally put it on the calendar. However, the salacious rhetoric of Gregg Williams' pregame speech and the revelation of the bounty program will ensure this regular-season matchup possesses the intensity of a playoff game.
Week 15 at Patriots
A couple of Kyle Williams gaffes prevented a Super Bowl XLVI matchup between these heavyweights, but this regular-season battle will certainly carry significant long-term ramifications for both squads' playoff aspirations.