"I think it will be easier for (him)," Vick told NFL Network on Tuesday during Nike's uniform unveiling in New York, adding that Jackson now is "satisfied."
Jackson signed a five-year, $48.5 million deal last month after earlier being hit with the franchise tag by the Eagles.
"We're very happy for DeSean," Vick said. "It was overdue. He finally got a chance to reap the benefits on how hard he worked."
But with the big contract, Vick said Jackson will face even greater expectations to produce like the player who made Pro Bowls in 2009 and 2010.
"We expect him to work harder than before and give the organization everything he can," Vick said.
It might be more difficult for Vick to find Jackson downfield on a regular basis now that left tackle Jason Peters could miss the entire 2012 regular season after rupturing his Achilles' tendon during an offseason workout in Texas.
"It's going to be tough," Vick said. "A lot of our guys have great rapport with Jason Peters (so) to have this injury this drastic, it's devastating. Our team has to continue to move forward and bounce back from it."