March 3, 2010 -- Manning has surgery to relieve pain in his neck caused by a pinched nerve.
May 23, 2011 -- Manning undergoes surgery by neurologist Richard Fessler in Chicago to repair a bulging disk in his neck.
Aug. 29, 2011 -- Colts activate Manning from the physically-unable-to-perform (PUP) list.
Sept. 8, 2011 -- Manning has a third neck surgery -- a "single-level anterior fusion" -- and is ruled out for the season opener, ending his streak of 227 consecutive starts, including the playoffs.
Sept. 18, 2011 -- Reports surface that Manning flew to Europe to undergo a stem-cell treatment on Sept. 8.
Jan. 2, 2012 -- Colts fire general manager Bill Polian.
Jan. 11, 2012 -- Colts hire Ryan Grigson as their new general manager.
Jan. 17, 2012 -- Colts fire coach Jim Caldwell.
Jan. 25, 2012 -- Colts hire Chuck Pagano as their new head coach.
Feb. 2, 2012 -- Manning's surgeon, Dr. Robert Watkins Sr., issues a statement that says the QB has been "medically cleared to play professional football." Irsay tweets that Manning has not been cleared to play for the Colts.
Feb. 14, 2012 -- Irsay tells The Indianapolis Star that Manning is welcome back if he'll take a pay cut.
Feb. 15, 2012 -- Sports Illustrated reports that Manning had a neck surgery sometime between the May 23 and Sept. 8 procedures. The report also says Manning wanted to play in December but a team physician ruled against it.
March 2, 2012 -- A video surfaces of Manning throwing long passes on a practice field at Duke University.
March 6, 2012 -- News breaks that the Colts are expected to release Manning on Wednesday.
March 8, 2012 -- $28 million option bonus due to Manning.