The NFL single-season records set by the Saints (13-3), who head into the playoffs on an eight-game winning streak, included offensive yards with 7,474, team yards passing with 5,347 and first downs with 416.
Brees, who was 28 of 35, finished with a record 468 completions this season, breaking Peyton Manning's 2010 mark of 450. He finished the season completing 71.6 percent of his passes, breaking his own 2009 NFL record 70.6 completion percentage.
Tight end Jimmy Graham had 97 yards receiving, finishing with an NFL record 1,310 for a tight end.
The Panthers finished the season at 6-10.
Copyright 2012 by The Associated Press