"It looks that way," Whisenhunt said.
Kolb (head) was listed as questionable for the game after being limited in practice all week. He's slowly been recovering from a concussion suffered last week against the San Francisco 49ers. He will be checked out Sunday morning before a final decision is made.
In Kolb's place, Skelton threw for 282 yards with three touchdowns and two interceptions while leading Arizona to an upset 21-19 win over San Francisco. If Skelton does start against Cleveland, it would be his fifth start of the season. He is 3-1 as the starter.
For a complete look at all injuries around the league, go to NFL.com's injury page.