The New York Jets officially ruled out LaDainian Tomlinson for the second consecutive game, shortly after a league source told NFL Network's Albert Breer that the running back wouldn't play while he recovers from a sprained medial collateral ligament in his left knee.
"If you're on a scale, he's sliding into that one (doubtful)," Ryan said. "He wants to go as badly as it gets. I want to make sure that he has protection from himself. I'm not going to force the issue, that's for sure."
The Bills have been ravaged by injuries, the latest to star running back Fred Jackson, who was placed on season-ending injured reserve with a broken left leg. C.J. Spiller replaced Jackson in Buffalo's starting lineup.
The Bills also were without safety George Wilson (neck), offensive tackle Demetrius Bell (shoulder), kicker Rian Lindell (shoulder) and wide receiver Naaman Roosevelt (shoulder). Wide receivers Stevie Johnson (shoulder) and David Nelson (illness) and newly signed running back Tashard Choice were active.
Visit www.nfl.com/inactives to see inactive players in every Sunday game.
The Associated Press contributed to this report.