Vick was not expected to play and was listed as questionable on the team's Friday injury report because of two broken ribs. Maclin, who missed his third consecutive practice on Friday, was also listed as questionable with shoulder and hamstring injuries.
Vick and Maclin were ruled out after Saturday's walkthrough and did not travel with the team.
Vick didn't practice this week because he broke his two lower ribs on the second play of the Eagles' 21-17 loss to Arizona in Week 10. He got up slowly after taking a hard hit to the side, but didn't tell anyone the extent of the injury and played the rest of the game. He was off target most of the game and finished 16 of 34 for 128 yards and two interceptions.
Young was 30-17 as a starter and went to two Pro Bowls in five seasons with the Tennessee Titans. He was one of several high-profile players Philadelphia signed after the lockout. So far, though, Young's only contribution was labeling the Eagles a "Dream Team" at his first news conference at training camp.
Second-year pro Riley Cooper will likely start in Maclin's place. Cooper doesn't have any catches this season.
The Eagles desperately need a victory over the first-place Giants to avoid being all-but-mathematically eliminated from playoff contention. The defending NFC East champions began this season with Super Bowl aspirations, but have failed to live up to those enormous expectations.
The Associated Press contributed to this report