It's the latest frustrating chapter this season for Hillis, who was ruled inactive for the road matchup against the NFC West leaders with a hamstring injury. Hillis has now missed three of Cleveland's seven games due to illness or injury.
Hardesty hasn't done much with his opportunity so far, rushing 73 times for 238 yards (3.3 yards per carry) and no touchdowns. He ran the ball 33 times for 95 yards in last week's 6-3 win over the Seattle Seahawks.
Visit www.nfl.com/inactives to see inactive players in every Sunday game.