Tuck, who was listed as questionable, had missed three consecutive games with neck and groin injuries.
Running back Brandon Jacobs (knee) also was active after missing the Giants' previous two games. Jacobs was listed as probable on the Friday injury report.
Dolphins running back Daniel Thomas and cornerback Vontae Davis were both deactivated with hamstring injuries, and offensive lineman Richie Incognito also was ruled out. Thomas has battled hamstring problems all season, but he played the past two weeks.
Visit www.nfl.com/inactives to see inactive players in every Sunday game.
The Associated Press contributed to this report.