Hillis returned to practice for the first time since Oct. 16 on Wednesday but suffered a setback and has missed the past two days. He was not on the field with his teammates Friday as the Browns went through their final practice before leaving for the West Coast.
Browns coach Pat Shurmur said Hillis will travel with the team and has not yet been ruled out.
"He'll be out there and we'll decide whether he's going to play or not," Shurmur said after practice. "We'll see."
Earlier this week, Shurmur said if Hillis is healthy, he'll start. If he can't play, Montario Hardesty will make his second straight start. Hardesty rushed for 95 yards on 33 carries in last week's 6-3 win over the Seahawks.
Hillis' season has been a constant soap opera with his contract negotiations to secure a long-term extension, a strep throat sickness that caused him to miss a game and the hamstring injury among the main issues that have dominated his second season in Cleveland. He has vowed to stop talking publicly about his contract.
"I'm not going to be a distraction," he said.
Joe Haden was limited in practice and is questionable with a knee injury. Tight end Benjamin Watson returned to practice but is is questionable after missing two days with post-concussion symptoms. Offensive lineman Tony Pashos is questionable with an ankle injury.
Kicker Phil Dawson (right thigh) and linebacker Scott Fujita (head) are probable after fully practicing Friday.
For a complete look at all injuries around the league, go to NFL.com's injury page.
The Associated Press contributed to this report.