Coach Chan Gailey sad Monday that Spiller will probably switch positions and play wide receiver while wideout Donald Jones recovers from an ankle sprain that is expected to sideline him for another month.
Spiller played some receiver in Sunday's loss to the New York Giants and had five receptions for 39 yards.
With Fred Jackson having a Pro Bowl-type season, Buffalo has not been able to get many carries for Spiller, a second-year player out of Clemson who was taken with the ninth overall pick in last year's draft.
"He's got good hands, you saw that [Sunday]. He catches the ball when you throw it to him," Bills quarterback Ryan Fitzpatrick said of Spiller. "He's tough because he's fast and they've got to respect his speed. He made a really nice catch coming over to the sideline, a 20-yard type catch [it went for 15 yards]. I mean, he really looked like a receiver on that. He did some good stuff. He's going to add some versatility. With Donald [Jones] being out we had to throw him out there. He surprised some people with how well he handled it."