Hester caught a 48-yard touchdown pass from Jay Cutler on Chicago's first possession and ran a kickoff back 98 yards early in the third quarter to extend his record for combined kick-return scores to 16.
Hester caught a pass at the end of the third quarte, and the Bears announced he was out early in the fourth.
Chicago also lost tight end Kellen Davis to an elbow injury.
Minnesota lost center John Sullivan and safety Jamarca Sanford to concussions. Sullivan was on the field for the Vikings' first series in the third quarter and then left the game. Sanford left midway through the quarter.
It was not clear how either injury happened.
Copyright 2011 by The Associated Press