» The Steelers were hit the hardest by injuries in Week 4, with the biggest postgame concern that QB Ben Roethlisberger had X-rays on a left foot injury and left the stadium in a walking boot. The Steelers also lost LB James Harrison (eye), RB Rashard Mendenhall (hamstring), DE Aaron Smith (foot) and LB Jason Worilds (quadriceps) against the Texans.
» It was also a tough day for the Texans, as WR Andre Johnson left during the second quarter with a right hamstring injury and RB Ben Tate also didn't return after suffering a groin strain during the first quarter.
» Eagles DE Trent Cole was carted to the locker room during the fourth quarter. NFL Network's Albert Breer reported that Cole has a hip injury that "definitely could be serious," according to a source, and would have an MRI on Monday. Eagles LT Jason Peters also limped off the field late during the fourth quarter with a hamstring strain, while DT Antonio Dixon was ruled out of the game with a left triceps injury. Coach Andy Reid said both would undergo MRI exams.
» The Rams announced DT Gary Gibson (right hip) and OG Jacob Bell (left hamstring) left with injuries during the first quarter against the Redskins. Michael Hoomanawanui took a blow to the head, according to The Associated Press, but the Rams did not have a diagnosis.
» Bears RG Chris Spencer, starting in place of Lance Louis, left during the first quarter against the Panthers with a hand injury. The Chicago Tribune reports Spencer's hand is broken, although he was able to finish the game.
» Patriots LB Jerod Mayo exited with a serious left knee injury during the second quarter against the Raiders. NFL Network's Albert Breer reported Mayo sprained the MCL in the knee, per a league source. The Boston Herald reported Mayo could be out up to six weeks. Defensive lineman Kyle Love also left with an ankle injury, and it's not believed RB Danny Woodhead returned after limping off the field during the second quarter. The Herald also reported Woodhead has an ankle injury.
» Seahawks coach Pete Carroll said WR Mike Williams suffered a concussion against the Falcons. Linebacker Matt McCoy (right knee) and DT Anthony Hargrove (hamstring) did not return following their injuries.