Landry remains the bigger concern. He's nursing a right hamstring injury and has yet to take part in a full practice since the opening of training camp. Shanahan said Friday that Landry has "been working a little bit through a few more drills" and will be listed as questionable.
"I want to get out there, but weâll see what happens," Landry said. "We'll see what happens tomorrow and Sunday. We got 48 hours."
Reed Doughty will again start if Landry can't play.
Orakpo sprained his ankle early in last week's win over the New York Giants but was able to stay in the game. He's been limited in practice all week and is also listed as questionable.
"I don't like missing nothing," Orakpo told the newspaper. "But you gotta be cautious and just take it real slow. ... Weâre going to see how it is, man. That's all I can say."
For a complete breakdown on all the latest injuries throughout the league, go to NFL.com's Injury Report.
The Associated Press contributed to this report.