All three were limited in practice Friday after Harris injured a toe in the opener against Dallas, and Holmes (knee and quadriceps) and Smith (ankle) were hurt during practice this week.
Coach Rex Ryan says he feels "good about David playing. The other two guys, it's questionable."
Both Holmes and Smith seemed to think they would be fine for the game. Holmes said Thursday: "Nothing to be worried about."
Ryan was asked if the Jaguars shouldn't even plan to face Holmes: "That's probably a good message to send to them," Ryan quipped. "Absolutely."
Copyright 2011 by The Associated Press