"M Colston broke his collarbone and will be out approx 4 weeks! Tough loss," Glazer tweeted Friday.
Colston had six catches for 81 yards in the Saints' 42-34 loss to the Green Bay Packers in Thursday night's opener. On the Saints' final drive of the game, Colston made a diving catch for a first down in Packers territory but appeared to favor his right shoulder after the play.
Colston had 84 receptions for 1,023 yards and seven touchdowns this past year.
With Colston out for a prolonged period and Lance Moore battling a nagging groin injury, the Saints are down their top two wideouts from 2010. The pressure will be on Devery Henderson and Robert Meachem to pick up the slack in the meantime, and if Thursday's game is any indication, Drew Brees won't hesitate to look for either receiver. Henderson and Meachem combined for 11 catches, 170 yards and two touchdowns against the Packers.