The Patriots announced Welker had a neck injury during the game but didn't give any updates afterward.
Welker was New England's leading receiver last season, catching 86 passes for 848 yards. He caught a 44-yard touchdown pass from Tom Brady in the second quarter Saturday for the Patriots' first touchdown of the game.
"He's a tough guy," Brady told the Herald. "There's nobody tougher than Wes Welker. He's mentally, physically, he's as good as there is. He's a huge part of our offense."
The Associated Press contributed to this report.