Indianapolis Colts wide receiver Pierre Garcon and running back Donald Brown did not travel with the team to Jacksonville and will miss Sunday's game against the Jaguars.
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Garcon and Brown missed practice all week with hamstring injuries, and Garcon also sat out of last week's game when Indianapolis (2-1) activated Blair White from the practice squad.
The Colts already had ruled out three players. Linebacker Kavell Conner is coming off foot surgery, receiver Anthony Gonzalez has a high ankle sprain and safety Bob Sanders is recovering from biceps surgery.
For the 1-2 Jaguars, safety Sean Considine is listed as doubtful with a hamstring issue. Linebacker Justin Durant (ankle) is out.
The Associated Press contributed to this report.
