NFL Network's Jason La Canfora reports Harris will be a game-time decision.
The leading tackler on the league's top-ranked defense missed two days of practice before returning Thursday. Harris was injured in the Jets' 37-0 win over the Bengals last Sunday, the result of what he thought was an illegal chop block.
Harris said the ankle felt "kind of stiff" after practice Thursday, but added that he hopes to play Saturday. Harris was unavailable for comment Friday because the team had no media availability before leaving for Cincinnati.
Cornerback Donald Strickland is also questionable with the same quadriceps injury that sidelined him last week.
The Associated Press contributed to this report