"I'll be all right," said Buckhalter, who wouldn't elaborate about his injury.
Buckhalter, who spent his previous eight NFL seasons with the Philadelphia Eagles, hurt the ankle on a sweep play. He finished the game with 37 yards on six carries, and he also had five catches for 55 yards.
Rookie Knowshon Moreno, the No. 12 overall pick in the April draft, took Buckhalter's place and had 65 yards on 14 carries and added a 9-yard touchdown catch. He might have a bigger role in the offense if Buckhalter is down for a while.
"Whatever they ask me to do, really," Moreno said. "We still have LaMont (Jordan) and some other guys who can come in and do the job also. We don't know how bad it (Buckhalter's injury) is, but we're just going to keep moving."
The Associated Press contributed to this report.