Edwards, who's listed as doubtful, missed practice all this week because of a lingering groin injury sustained in the first half of Buffalo's loss to San Francisco on Nov. 30.
Losman was ineffective and inconsistent last week in the Bills 16-3 loss to Miami in Toronto, completing 13 of 27 passes for 123 yards. He also threw a costly interception in the third quarter on a first down play from the Dolphins 3.
Starting cornerback Jabari Greer won't play in his fourth straight game because of a right knee injury sustained against Cleveland on Nov. 17.
Copyright 2008 by The Associated Press.